SciELO - Scientific Electronic Library Online

 
vol.20 número1Hantavirus en roedores de La Ciudad de Buenos Aires circulación de hantavirus en Oligoryzomys Flavescens en Ciudad de Buenos Aires, ArgentinaIncidencias en trichostrongylídeos en relación con los patrones de remolinos frontales en bovinos índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

Compartilhar


InVet

versão On-line ISSN 1668-3498

Resumo

SOTO, P. et al. Experimental model to assess the Tritrichomonas foetus vaccine- induced effects. InVet [online]. 2018, vol.20, n.1, pp.23-36. ISSN 1668-3498.

The purpose of this work was to present an experimental murine model as an alternative to the bovine one, to evaluate the efficacy of experimental vaccines against Tritrichomonas foetus. The vaccines employed consisted of inactivated protozoa with different formulations: (A) with oil adjuvant, (B) aqueous vaccine, (C) aqueous vaccine with dimethyl sulphoside. Seventy female BALB/c mice were used and distributed in 7 experimental groups; each group received 2 doses of vaccine, two groups received a vaginal booster at the time of the second dose. Fifteen days after the second dose, all animals were challenged by vaginal instillation with T. fetus. Blood samples and vaginal mucus were taken until day 30 post infection. The immune response was evaluated by ELISA and the vaginal infection assessed by vaginal mucus culture in the TYM medium. The greatest immune response was related to a lower number of infected animals post challenge and a rapid elimination of the protozoa of the reproductive tract. These results allow us to present an alternative experimental model and inexpensive to evaluate power test of current commercial vaccines and new developments of immunogens against bovine trichomonosis

Palavras-chave : Tritrichomonas foetus; Mouse model; Vaccine.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons