Resumo

CATUOGNO, M.S; MONTENEGRO, M.A; RAMIREZ, G.V  e  SANCHEZ NEGRETTE, M. Efectos del ácido butírico sobre la carcinogénesis experimental de colon inducida por 1,2-dimetilhidrazina en ratas. Rev. vet. [online]. 2013, vol.24, n.1, pp.32-38. ISSN 1669-6840.

Epidemiological studies in human beings link fatty diets with the development of colon and rectum cancer. However, experimental studies on laboratory animals have determined that several components of bovine's milk fat such as butyric acid are considered to be potential inhibitors of carcinogenesis. The aim of this work was to study the anticancerigenous effect of butyric acid on an experimental carcinogenesis model of colon in rats induced by 1,2-dimethylhydrazine (DMH). One hundred and ten male Wistar 6 weeks old rats weighing 150 g, were used. Animals were randomly separated in groups with and without butyric acid supplementation. They were divided also according to DMH weekly administration, in different experimental groups of 17 and 5 weeks respectively. The results support the fact that the development and biological behaviour of the colon cancer might be modified through diet changes.

Palavras-chave : Rat; Butyric acid; Carcinogenesis; Colon.

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