Resumo

VANDEERVEEN, M. P. et al. Study of the glucose/mannose glycoconjugate in the gastric mucosa of pigs diagnosed with Helicobacter pylori. Rev. vet. [online]. 2021, vol.32, n.1, pp.37-42. ISSN 1669-6840.  http://dx.doi.org/10.30972/vet.3215631.

20.

Helicobacter pylori, a Gram negative bacillus, is associated with gastritis, ulcer, and gastric cáncer. The worldwide prevalence of H. pylori infection is greater than 50%, constituting a public health problem. Different species of Helicobacter were described, which affect both animáis and humans, and may be responsible for zoonoses. The colonization process of this bacterium depends largely on its binding to glycoconjugates present in the gastric mucosa of the host. The pig represents the animal model of choice for the study of infection by this bacterium. The objective of the present work was to analyze the behavior of the glucose/mannose glycoconjugate in the gastric mucosa of pigs affected by gastritis caused by Helicobacter sp. Samples from the antral región of the stomach of crossbred pigs were used, obtained from slaughterhouse in the Río Cuarto (Argentina). The samples were classified into different study groups according to the type of gastritis and the presence or absence of Helicobacter sp. A lectin histochemistry study for glucose/mannose glycoconjugate was carried out, the evaluated under microscope and statistical analysis performed. The results obtained indícate that there were no significant differences between the groups in the glucose/mannose expression in epithelium and gastric glands, but there were significant differences in the expression of this glycoconjugate in lamina propria between Helicobacter sp positive acute gastritis with respect to the Helicobacter sp negative acute gastritis groups and with normal mucosa group. This results reveal that there is relationship between the increase in glucose/mannose expression and the presence of Helicobacter sp in the lamina propria of pig gastric mucosa.

Palavras-chave : Helicobacter pylori; pigs; gastric mucosa; lectin-histochemistry; glucose / mannose..

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