Resumo

LOPEZ AGUERO, LC  e  DITTRICH, RJ. Biopharmacological alterations of procaine used by via intradermal. Rev. argent. dermatol. [online]. 2010, vol.91, n.4, pp.30-40. ISSN 1851-300X.

It has been shown that local anesthetics have many effects on different cells. They act directly at the plasma membrane and interact with membrane lipid and protein producing molecular disorder, inhibition of fibroblast activity, induces vacuolization of many cell types and, among other actions, decreases the synthesis of collagen. Procaine selectively inhibits ATP-calcium dependent, blocking the entry of extracellular calcium to the cell, alters the function of microtubules and microfilaments, changes cell shape and the distribution of membrane receptors, inhibits various enzymes like phospolipase A2 involved in lipolysis, alter the DNA and cell cycle. Despite the fact that local anesthetics (e.g. procaine) have been used in mesotherapy formulas as an "indispensable vector" for over 55 years, we must be careful in its use as a diluter of formulas. Based on these tissue changes, we consider it important to know the specific actions of procaine in different cell structures.

Palavras-chave : Procaine; Intradermotherapy; Mesotherapy.