Resumo

GUTIERREZ, Leandro G et al. A case of chronic myeloid leukemia with Philadelphia chromosome variant. Rev. cienc. tecnol. [online]. 2017, n.27, pp.46-50. ISSN 1851-7587.

Among the CML there is a fraction of cases (5-10%) in which the Philadelphiachromosome (Ph1) originates from variant translocations (Ph1 variant), in which there are autosomes involved other than the classic 9 and 22. Here we report a case of CML where a variant Ph1 chromosome was originated from a complex translocation involving chromosomes 3, 9 and 22 [t(3,9,22)(p21,q34,q11)]. FISH analysis suggests that the mechanism of translocation occurred in a single step. Furthermore, the RT-PCR analysis also showed the presence of the classical molecular rearrangement corresponding to the BCR/ABL1 p210 isoform. The patient showed no significant variations in the parameters of clinical response (hematologic, cytogenetic, and molecular response) from those patients carrying a standard Ph1 chromosome.

Palavras-chave : Chronic myeloid leukemia; Philadelphia chromosome; Variant translocation.

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