Resumo

CHIESA, Ignacio Javier et al. Circulación de virus de influenza A y cepas resistentes a oseltamivir en el período invernal del año 2013. Rev. am. med. respir. [online]. 2015, vol.15, n.4, pp.301-305. ISSN 1852-236X.

Initially the circulating influenza virus A(H1N1)pdm09 was susceptible to neuraminidase inhibitors oseltamivir and zanamivir. Virtually all resistant viruses possess a substitution at codon 274 of the neuraminidase gene which produces a change of the amino acid histidine (H) to a tyrosine (Y). The aims of the study were to perform a retrospective analysis of samples studied in the Laboratory of Genomic Medicine - MANLAB for influenza A during the period June to August 2013 in Buenos Aires, and to determine the presence of the H274Y mutation. 1783 samples from patients with a presumptive diagnosis of influenza A(H1N1) pdm09 were studied, the virus was detected in 171 samples (9.6%). Then, we studied the presence of the mutation H274Y. Only two samples showed the characteristic resistance mutation. Methods for detecting oseltamivir-resistant A(H1N1)pdm09 influenza strains are needed to assist physicians in the selection of appropriate antiviral therapy for influenza treatment.

Palavras-chave : Influenza A; H1N1; Oseltamivir resistance.

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