Resumo

COMERT, ule et al. EVALUACIÓN DEL TABAQUISMO COMO FACTOR DE RIESGO ADICIONAL DE ENFERMEDADES CARDIOVASCULARES EN PACIENTES EN HEMODIÁLISIS SEGÚN NIVELES ELEVADOS DE IL-6, TNF± , hs-CRP y ENDOTELINA-1. Rev. nefrol. dial. traspl. [online]. 2018, vol.38, n.2, pp.111-125. ISSN 2346-8548.

Introduction: Cardiovascular diseases (CVD) are one of the most common causes of mortality in chronic kidney disease. Smoking is a well defined risk factor for atherosclerotic cardiovasculardisease. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), high sensitive C-reactive protein (hsCRP) and endothelin-1 (ET-1) have found elevated in chronic inflammatory process. We aimed to evaluate if IL-6, TNF-alpha, hsCRP and ET-1 are increased in smoker hemodialysis (HD) patient compared to non-smoker HD individuals to potentially refer us cardiovascular diseases noninvasively. Material and methods: 80 smoker and 50 non-smoker maintenance hemodialysis male patients with similar demographic characters, dialysis and support treatment and metabolic profile. In addition to routine tests, we took samples for evaluating IL-6, TNF-alpha, hsCRP and endothelin-1. P values were measured. Results: In smoker HD patients, IL-6, TNF-alpha, hsCRP and endothelin-1 levels were found increased level statistically significant compared to non-smoker indiviuals. Conclusion: This study may refer us that smoking is an additional risk factor among HD individuals by increased levels of IL-6, TNF-alpha, hsCRP and ET-1.

Palavras-chave : interleukin-6; tumor necrosis factor-alpha; high sensitive C-reactive protein; endothelin-1; hemodialysis; renal dialysis; smoking.

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