Resumo

PEDREANEZ, Adriana et al. Elevación del índice neutrófilo/linfocito y su relación con la proteína C reactiva en pacientes con diabetes mellitus tipo 2. Rev. Soc. Argent. Diabetes [online]. 2021, vol.55, n.3, pp.77-83. ISSN 0325-5247.

Introduction: the ratio between the absolute neutrophil count and the absolute lymphocyte count (neutrophil/lymphocyte ratio, NLR) has become a crucial marker of systemic inflammation in recent years, and its elevation has been described as being related to numerous chronic inflammatory diseases.

Objectives: to determine the neutrophil/lymphocyte ratio (NLR) in patients with type 2 diabetes mellitus (T2DM), to compare with non-diabetics and to establish its correlation with the concentration of ultrasensitive C-reactive protein in a population of the town of Riobamba, Ecuador.

Materials and methods: a descriptive, correlational, cross-sectional, research was conducted from July 2019 to February 2020. Eighty individuals were selected to participate in the project, 25 control subjects and 55 patients with a diagnosis of T2DM. Each subject had a fasting blood sample drawn for the determination of glucose, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, ultrasensitive C-reactive protein (hs-CRP), glycosylated hemoglobin (HbA1c), total leukocyte count, neutrophils and lymphocytes.

Results: a significant increase in glucose concentration (p<0.0001), HbA1c (p<0.0001), body mass index (BMI) (p<0.0001), hs-CRP (p<0.0001), absolute neutrophil count (p=0.001), absolute lymphocyte count (p=0.04), and NLR (p=0.0005), and a significant reduction in HDL cholesterol (p=0.02), were found in patients with T2DM vs controls. A po-sitive correlation (p<0.0001; r=0.7774) was observed between NLR and hs-CRP in patients with T2DM.

Palavras-chave : diabetes; inflammation; neutrophil/lymphocyte ratio.

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