Abstract

BARAN, Enrique José. Compuestos de germanio en Farmacología y Medicina. Acta bioquím. clín. latinoam. [online]. 2023, vol.57, n.1, pp.99-106. ISSN 0325-2957.

After the presentation of the most relevant characteristics of the chemistry of germanium (IV), the pharmacological effects of some of its organometallic compounds are discussed, in particular those of spirogermanium, the so-called Ge-132, the germatranes and the organogermanium sesquisulfides. Studies with porphyrinic compounds and other macrocyclic ligands, as well as the substitution of Si by Ge in the fungicidal compound flusilazole are also mentioned. Finally, the use of 69Ge in Nuclear Medicine is analysed, and brief comments on the toxicological effects of germanium are also made.

Keywords : Pharmacology; Medical applications; Germanium; Organometallics; Toxicology.

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