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Revista americana de medicina respiratoria
versión On-line ISSN 1852-236X
Resumen
UBAL, Leonardo German et al. Influence of SARS-CoV-2 on the Progression of Infection to Tuberculous Disease. Presentation of 3 Cases. Rev. am. med. respir. [online]. 2023, vol.23, n.1, pp.101-106. ISSN 1852-236X. http://dx.doi.org/10.56538/ramr.hyau6023.
Introduction:
SARS-CoV-2 is likely to favor the transition from infection to tuberculous disease. Although information is limited, there is progress in understanding the inter action between COVID-19 and tuberculosis. New investigations yielded unexpected similarities in the pathogenesis and evolution of the coinfection. Prolonged lymphopenia, hyperinflammation, lung tissue injury, and imbalance in CD4+ T-cell subsets associated with COVID-19 could propagate M. tuberculosis infection and disease progression.
Case reports:
we present three young patients, without comorbidities, with risk fac tors for latent tuberculous infection, diagnosed with pulmonary tuberculosis post mild COVID-19, with symptomatic treatment (not corticosteroids).
Discussion:
these cases raise the probable impact of SARS-CoV-2 in the transition from latent tuberculous infection to disease, excluding the already proven influence of corticosteroids and severe forms of COVID-19. There is increasing evidence to support this idea.
Palabras clave : COVID-19; SARS-CoV-2; Tuberculosis.